Nawab Mushtaq Ahmed Khan had worked in the Nazim State Railways before partition as the General Manager and had also been responsible for the launching of road bus service connecting different cities in Hyderabad Deccan State of the Nizam.
He came to Karachi in 1947 after being appointed as the Agent General of Hyderabad State in Pakistan and served in that capacity for sometime, even after the fall of Hyderabad State to Indian aggression. He later went to Lahore and worked as chairman of the Punjab Road Transport Board and later for the West Pakistan Road Transport Board.
After retirement, he took up permanent residence in Lahore and managed his landed property in Jaranwala. Nawab Mushtaq Ahmed Khan also wrote a book on the fall of Hyderabad and his work especially in Karachi as the Agent General of Hyderabad.